HSV herpes simplex virus cytokine induced inflammation prostaglandin ctcl
A 74-year old Caucasian woman was being treated for cutaneous T-cell lymphoma (CTCL). The Aldara/imiquimod she was using in her treatment of this incurable CTCL disease triggered the activation and out-break of herpes simplex virus (HSV), a known side-effect of Aldara.
Topical Imiquimod Therapy for Cutaneous T-Cell Lymphoma
Excerpts from Article:
Adverse skin reaction included (among others) scarring as a consequence of cytokine induced inflammation……..
…imiquimod has been shown to increase levels of prostaglandin E2 , which has been associated with the activation of herpes simplex virus (HSV).
Imiquimod therapy has been associated with recurrences of HSV in patients with a history of facial HSV.
Author(s): Jennifer H. Do, MA, MD - Susan S. McLaughlin, MA, MD - Anthony A. Gaspari, MD
Source: Medscape – WEBMD posted 10/29/2003